Classification of Epileptic EEG Signals by Wavelet based CFC

Electroencephalogram, an influential equipment for analyzing humans activities and recognition of seizure attacks can play a crucial role in designing accurate systems which can distinguish ictal seizures from regular brain alertness, since it is the first step towards accomplishing a high accuracy computer aided diagnosis system (CAD). In this article a novel approach for classification of ictal signals with wavelet based cross frequency coupling (CFC) is suggested. After extracting features by wavelet based CFC, optimal features have been selected by t-test and quadratic discriminant analysis (QDA) have completed the Classification.Comment: Electroencephalogram; Wavelet Decomposition; Cross Frequency Coupling;Quadratic Discriminant Analysis; T-test Feature Selectio

The Study of psychometric properties of pregnancy related anxiety questionnaire

Background and aims: Pregnancy anxiety is a particular emotional state tied to pregnancy-specific concerns, such as worries about maternity and infant health. The aim of this study was confirmatory factor analysis of Pregnancy Related Anxiety Questionnaire (PRAQ) that was designed in Iranian pregnant women population. Methods: This research was a descriptive analytic study After confirming the validity and content for psychometric of tool, 170 pregnant women in health centers of Kerman city were selected by convenience sampling and completed PRAQ questionnaire and Beck Anxiety Inventory. In this study, Confirmatory factor analysis and concurrent validity were used to evaluate the validity of models; and test-retest and coefficients Cronbach's alpha test were used in SPSS 19 and the AMOS software to evaluate reliability of models. Results: Confirmatory factor analysis gave an acceptable value for the latent (PRAQ) in the question scale and level 5 of micro-scale. Also, a significant correlation between the components and the overall scale of the PRAQ questionnaire with the Beck Anxiety Inventory confirmed concurrent validity of questionnaire. Reliability of questionnaire is confirmed based on Cronbach's alpha coefficient value of 0.78 that calculated 0.69 to 0.76 for the five factors. A month later, reliability coefficient amplitude of test-retest on 40 pregnant women was between 0.65 to 0.72 (P<0.01) which shows the reliability of PRAQ over time. Conclusion: The short form of pregnancy anxiety questionnaire has the necessary psychometric properties. In this study, five factors extracted in the PRAQ were adapted with the factors extracted from the original version. It is recommended using this tool for diagnosis of anxiety and concerns of women during pregnancy

Cost-effectiveness of remdesivir for the treatment of hospitalized patients with COVID-19: a systematic review

Abstract Background Remdesivir is being studied and used to treat coronavirus disease 2019 (COVID-19). This study aimed to systematically identify, critically evaluate, and summarize the findings of the studies on the cost-effectiveness of remdesivir in the treatment of hospitalized patients with COVID-19. Methods In this systematic review, PubMed, EMBASE, Web of Science, SCOPUS, and the Cochrane Library were searched for studies published between 2019 and 2022. We included all full economic evaluations of remdesivir for the treatment of hospitalized patients with COVID-19. Data were summarized in a structured and narrative manner. Results Out of 616 articles obtained in this literature search, 12 studies were included in the final analysis. The mean score of the Quality of Health Economic Studies (QHES) for the studies was 87.66 (high quality). All studies were conducted in high-income countries (eight studies in the USA and one study in England), except for three studies from middle-to-high-income countries (China, South Africa, and Turkey). Six studies conducted their economic analysis in terms of a health system perspective; five studies conducted their economic analysis from a payer perspective; three studies from the perspective of a health care provider. The results of five studies showed that remdesivir was cost-effective compared to standard treatment. Furthermore, the therapeutic strategy of combining remdesivir with baricitinib was cost-effective compared to remdesivir alone. Conclusions Based on the results of the present study, remdesivir appears to be cost-effective in comparison with the standard of care in China, Turkey, and South Africa. Studies conducted in the United States show conflicting results, and combining remdesivir with baricitinib is cost-effective compared with remdesivir alone. However, the cost-effectiveness of remdesivir in low-income countries remains unknown. Thus, more studies in different countries are required to determine the cost-effectiveness of this drug